A primetime battle on Monday Night Football features the San Francisco 49ers (1-2) hosting the Los Angeles 1). This will be a battle between two offensive masterminds in Kyle Shanahan and Sean McVay. McVay is 4-7 against Shanahan head-to-head, and the 49ers will be without star left tackle Trent Williams (high-ankle sprain). Both teams are 1-2 against the spread this season.

San Francisco has a dominant and forceful defense. This unit owns an aggressive defensive line that puts pressure and gets after the quarterback. They are currently second in total yards allowed (227). Defensive lineman Nick Bosa is the best player up front for the 49ers. Bosa can win with either speed or power while owning a relentless motor.

Los Angeles has plenty of star power on this roster. They have cornerback Jalen Ramsey and defensive lineman Aaron Donald leading the defensive unit. Ramsey is a shutdown corner who is a physical and reliable tackler. The five-time Pro Bowl selection has elite range and length to dispute opposing receivers and quarterbacks. The Florida State product has 16 total tackles, four pass deflections, and one interception.